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| Teixeira,C.; Gomes,R.. |
| Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human vaccines; Animal models; Malaria; Leishmaniasis. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109 |
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| Teixeira,C.; Pires,I.; Ferreira,S.; Vieira-Pinto,M.. |
| O presente estudo teve como principais objetivos conhecer a taxa de ocorrência de lesões melanocíticas (melanose, melanocitomas e melanomas) em suínos abatidos para consumo e identificar possíveis padrões de distinção e de classificação macroscópica dessas lesões. Para tal, procedeu-se à recolha de lesões melanocíticas em matadouro, durante oito meses, e à sua avaliação macroscópica e microscópica. Os resultados deste estudo demonstraram que as melanoses foram as lesões melanocíticas mais frequentemente encontradas (74,04%) e que, relativamente às lesões tumorais, os melanomas (malignos) foram os mais frequentes (21,15%) comparativamente com os melanocitomas (benignos) (4,81%). Pela análise comparativa das características macroscópicas e microscópicas,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Suínos; Melanose; Melanocitoma; Melanoma; Abatedouro. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000300026 |
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| Reis,K.P.; Sperling,L.E.; Teixeira,C.; Sommer,L.; Colombo,M.; Koester,L.S.; Pranke,P.. |
| The central nervous system shows limited regenerative capacity after injury. Spinal cord injury (SCI) is a devastating traumatic injury resulting in loss of sensory, motor, and autonomic function distal from the level of injury. An appropriate combination of biomaterials and bioactive substances is currently thought to be a promising approach to treat this condition. Systemic administration of valproic acid (VPA) has been previously shown to promote functional recovery in animal models of SCI. In this study, VPA was encapsulated in poly(lactic-co-glycolic acid) (PLGA) microfibers by the coaxial electrospinning technique. Fibers showed continuous and cylindrical morphology, randomly oriented fibers, and compatible morphological and mechanical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coaxial electrospinning; VPA; Spinal cord injury. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400606 |
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